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EC number: 262-967-7 | CAS number: 61788-32-7
Terphenyl, hydrogenated was very well tolerated in 51 human individuals after tests according to the Shelanski repeat insult test and was shown to be not sensitising.
SUMMARY: Number of Responses in each Grade
0 – No visible irritation, or no difference from surrounding, untreated skin.
Ø – Change in appearance of skin of contact site not attributed to test material.
? – Questionable status as to presence of any change.
½ - Mild erythema covering less than half of the contact site.
1+ - Erythema confined to the contact site and exceeding that of the untreated skin.
2+ - Erythema confined to the contact site and definitely exceeding that of untreated skin, papules may or may not be present.
3+ - Erythema, with some degree of induration, papules may or may not be present.
4+ - Erythema, induration, with one or more complications such as: extension beyond margins of contact area, vesiculation, ulceration.
NP – No patch applied.
np – No patch applied, reasons unrelated to test material.
A – Absent.
NS – New site.
There was no evidence that the test material acted as a sensitizer in any of the 51 individuals in the Shelanski repeat insult test. It is unlikely that this material would present a danger of irritation or sensitization in normal intended use.
A key study for sensitisation was performed in 51 humans with Terphenyl, hydrogenated according to Shelanski repeat insult method, this method was considered to be reliable, adequate and relevant (Product investigations Inc., 1979). There was no evidence that the test material acted as a sensitizer in any of the individuals. Further, a supportive study was available according to the same method in 50 individuals. There was no evidence that the test material acted as a sensitizer. It is therefore unlikely that this material would present a danger of irritation or sensitization in normal intended use.
The endpoint does not meet classification criteria according to EU and/or CLP criteria.
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