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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012-01-19 to 2012-01-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Dissociating properties:
yes
No.:
#1
pKa:
5.14
Temp.:
20 °C
Remarks on result:
other: No details on temperature are provided, however ambient temperature is anticipated.

The pKa from the estimation test was 5.18.

Conclusions:
The dissociation constant of the substance was determined to be 5.1 at ambient temperature.
Executive summary:

The dissociation constant of the test item was determined according to OECD guideline 112 by applying the titration method. The dissociation constant of the substance was determined to be 5.1 at ambient temperature.

Description of key information

The dissociation constant of NMMO was determined to be 5.1 at ambient temperature following a GLP study conducted in accordance with guideline OECD 112 using the titration method (Younis, 2011).

Key value for chemical safety assessment

pKa at 20°C:
5.1

Additional information

Although the temperature was not reported it was assumed that the study was conducted at ambient temperature.