Registration Dossier
Registration Dossier
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EC number: 203-490-6 | CAS number: 107-43-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.4.1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study was performed with a modified OECD method 107. Instead of three replicates, results were calculated using only one measurement.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- The results were calculated only from one flask-shaking measurement.
- Principles of method if other than guideline:
- Modified from OECD guideline method 107. The amounts of analytes after shaking were analysed by HPLC. The results were calculated from one flask-shake measurement.
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- <= 0.001
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Type:
- log Pow
- Partition coefficient:
- <= -3.1
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Conclusions:
- The water/n-octanol partition coefficient of the substance was determined by using a modified version of OECD guideline method 107. The amounts of analytes after shaking in both phases were determined by using HPLC. The repeatability of injection before analyses was acceptable. The results were calculated only from one flask-shaking measurement. The pH-value was not available nor documented in the analysing report.
Pow of the substance at 20 C was 0.00081. - Executive summary:
The water/n-octanol partition coefficient of the substance was determined by using a modified version of OECD guideline method 107. The amounts of analytes after shaking in both phases were determined by using HPLC. The repeatability of injection before analyses was acceptable. The results were calculated only from one flask-shaking measurement. The pH-value was not available nor documented in the analysing report.
Pow of the substance at 20 C was 0.00081.
Reference
Description of key information
Determined by using a modified OECD guideline method 107. The analysis was performed by HPLC, and the study was performed at the manufacturer's laboratory using best practice found.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.1
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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