Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

It is known from similar substances that the glycidyl ether substituents are determining the toxicity profile of the substance.  It is considered that  genotoxicity and skin sensitization and irritation are due to the  glycidyl ether substituent. Glycidyl ethers are rapidly cleaved by hydrolysis by epoxyde hydrolases present in the skin, in the liver and in most tissues. Epoxyde hydrolases are therefore a very efficient mechanism of detoxification.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The available toxicity data show that the substance as described in section 1 is bioavailable. No data on the absorption rate is available. The substance is not lipophilic and therefore there is a very low bioaccumulation potential. The substituent determining toxicity are likely the glycidyl ethers because they can bind to DNA and/or protein. Following absorption the glycidyl ether functions of the substance are considered to be rapidly hydrolysed and the substance detoxified. At high doses this metabolic pathway may be overloaded resulting in the presence of the unmetabolised substance in circulation. It is considered that the hydrolysed substance is either further metabolised or excreted by the kidneys.