Registration Dossier
Registration Dossier
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EC number: 269-929-9 | CAS number: 68391-11-7 The complex combination of polyalkylated pyridines derived from coal tar distillation or as high-boiling distillates approximately above 150°C (302°F) from the reaction of ammonia with acetaldehyde, formaldehyde or paraformaldehyde.
Endpoint summary
Administrative data
Description of key information
Additional information
Pyridine, alkyl derivs. was shown to be inherently biodegradable. In the key study Pyridine, alkyl derivs. was tested according to OECD Guideline 302 C (Inherent Biodegradability: Modified MITI Test (II). After 28 days of exposure, the rate of degradation amounted to 56.6 % when estimated using the ratio BOD/COD. In a supporting study according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) Pyridine, alkyl derivs. showed limited biodegradation, most likely due to cytotoxicity effects.
In addition to biodegradation studies with Pyridine, alkyl derivs., a ready biodegradation study and a study on inherent biodegradation were carried out using the model constituent 5-ethyl-2-methylpyridine (MEP, CAS no.: 104-90-5, EC no.: 203-250-0). The read-across between the UVCB substance and the model constituent is justified. In a study according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test) MEP was determined ready biodegradable, but failing the 10-day window. In a study according to OECD 302 B (Zahn-Wellens test) MEP showed inherent biodegradation, with 98.7 % degradation in 21 days.
Experimental determination of biodegradation in water and sediment and soil were waived.
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