Registration Dossier
Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches
- Author:
- Zhang Q, Ji C, Yin X, Yan L, Lu M, Zhao M
- Year:
- 2 016
- Bibliographic source:
- Environ Pollut, 210, 27-33
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Results and discussion
Any other information on results incl. tables
No agonistic or antagonistic activity of Triphenyl phosphate against the TRß receptor was observed. While the publication reported results with CHO-K1 cells and GH3 cells only those with the CHO-K1 cells are reported here as this is a hamster cell line, which is considered relevant in this IUCLID chapter. GH3 cells are rat pituitary adenoma cell lines instead.
Applicant's summary and conclusion
- Conclusions:
- No agonistic or antagonistic activity of Triphenyl phosphate against the TRß receptor was observed.
- Executive summary:
Potential interaction of TPP with TRß receptor in CHO-K1 cells were assessed in an non-standard in vitro test system with the Dual-Luciferase® Reporter Assay System purchased from Promega (Madison, WI, USA). 0.1 % DMSO was used as a solvent. The test system is static and the bioassays lasts 24 hours. T3 hormone was used as a positive control. The bioassay allows to assess interactions which are agonistic or antagonistic against TRß receptor.
No agonistic or antagonistic activity of Triphenyl phosphate against the TRß receptor was observed. Thus, TPP showed no potential to interact with
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