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EC number: 203-473-3
CAS number: 107-21-1
aquatic toxicity of the 'ethylene glycol and higher glycols' (mono-,
di-, tri-, tetra- and pentaethylene glycol) is evaluated as a category.
The glycol category includes the assessment for the described reaction
mass of 2,2'-(ethylenedioxy)diethanol 3,6,9-trioxaundecane-1,11-diol, as
a glycole mixture. Further information on the category approach is
described in a separate document, which is attached to this IUCLID-File
in Chapter 13.
on all three trophic levels (fish, daphnia, algae) are available to
describe the aquatic toxicity of the glycol category members. The
available data cover short and long-term effects on all three trophic
levels. Due to the fact, that not for each single substance data for all
required endpoints are available, a weight of evidence approach is used,
which includes additional information based on QSAR calculation with the
EpiWin-Program ECOSAR v1.11. Measured data as well as estimated data
demonstrate, that all glycols within the category are not harmful to
aquatic organisms. No adverse effects on aquatic organisms occurred up
to concentrations above 100 mg/L.
the QSAR calculations it can be expected that algae are slightly more
= 479 - 8450 mg/L) than invertebrates (ChV = 690 – 17475 mg/L) or fishes
(ChV = 2629 – 8666 mg/L). Therefore the chemical safety assessment is
based on the algae data. Within the category several studies on algae
are available. In one case (pentaethylene glycol, CAS 4792-15-8) only a
limit test with a concentration of 100 mg/L was conducted, in which no
effects were observed. From the other available information it can be
expected that the real NOEC is far above the limit test concentration of
100 mg/L. Nevertheless, as a worst case assumption the limit test
concentration of 100 mg/L was used as NOEC value for the PNEC derivation.
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