Registration Dossier
Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other: abstract
- Title:
- Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits.
- Author:
- Carney EW, Pottenger LH, Bartels MJ, Jaeckh R, Quast JF
- Year:
- 1 998
- Bibliographic source:
- Toxicology Letters 95: 208
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- ethane-1,2-diol
Constituent 1
Test animals
- Species:
- other: rat and rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Duration and frequency of treatment / exposure:
- gd 10 rats and gd 9
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day
- Dose / conc.:
- 2 500 mg/kg bw/day
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Key result
- Toxicokinetic parameters:
- other: Key findings: (1)maternal blood concentrations of EG were comparable in rats and rabbits; (2)levels of GA in maternal blood and EEF were 3 to 36-fold lower in rabbits than in rats; (3)in rats, concentrations of GA were higher in EEF than in maternal blood
Applicant's summary and conclusion
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