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EC number: 203-473-3 | CAS number: 107-21-1
BASF (1968) reported an acute oral LD50 value of 7712 mg/kg for male and female rats.
Tyl (1985) reported an acute inhalative LC50 value of > 2.5 mg/L air for a six-hour exposure for male and female rats.
Acute oral toxicity:
BASF (1968) reported an acute oral LD50 value of 7712 mg/kg for male and female rats. Animals were given doses of about 3200, 6400, 8000 and 10000 µL/kg. Clinical signs seen were depression and narcosis. No mortalities were seen in the low dose group, 5 of 20 rats died in th 6400 µL/kg dose group, 16 of 20 rats died in the 8000 µL/kg dose group and 19 of 20 rats died in the 10000 µL/kg dose group.
Acute inhalation toxicity:
BASF (1961) reported an inhalation hazard test. Rats inhaled a saturated atmosphere at 20°C for 8 hours. No symptoms and no mortalities were observed.
Tyl (1985) reported a teratogenicity study using rats and mice. Concentrations of 0.15, 1 or 2.5 mg/L were given as aerosol concentrations using male and female rats. From this study, an acute inhalative LC50 value was derived being > 2.5 mg/L air for a six-hour exposure for male and female rats.
According to the results mentioned above, classification proposal concerning acute inhalation toxicity could not be done.
Acute dermal toxicity:
Tyl (1988) reported a developmental toxicity study using mice. Male and female animals were given doses of about 404 mg/kg, 1677 mg/kg and 3549 mg/kg under occlusive conditions. From this study, an acute dermal LD50 value of > 3500 mg/kg for male and female mice was derived.
According to the results of this developmental toxicity study, classification regarding acute dermal toxicity is not warranted.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008 The substance is legally classified for acute toxicity category 4 (H302: "Harmful if swallowed") according to Annex VI REACH Regulation. However, regarding available reliable experimental test data provided in this dossier the substance would not need to be classified for acute toxicity under Regulation (EC) No 1272/2008, as amended for the eighth time in Regulation (EU) No 2016/218.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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