Ethane-1,2-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Early study report, short study description.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

according to BASF-internal standards

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethane-1,2-diol

EC Number:

203-473-3

EC Name:

Ethane-1,2-diol

Cas Number:

107-21-1

Molecular formula:

C2H6O2

IUPAC Name:

ethane-1,2-diol

Specific details on test material used for the study:

30% solution in aqua dest.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

3200, 6400, 8000, 10000 mL/Kg bw

No. of animals per sex per dose:

20

Control animals:

no

Details on study design:

Recording of symptoms for 7 days after application.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

7 712 mg/kg bw

Based on:

test mat.

Mortality:

Dead animals after 7 days observation period:
19/20 in 10000 mL/kg bw dose group
16/20 in 8000 mL/kg bw dose group
5/20 in 6400 mL/kg bw dose group
0/20 in 3200 mL/kg bw dose group

Clinical signs:

other: depression, narcosis.

Gross pathology:

Animals that died: kidney damage