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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Evaluation of the Developmental Toxicity of Ethylene Glycol Aerosol in the CD Rat and CD-1 Mouse by Whole-Body Exposure.
Author:
Tyl RW, Ballantyne B, Fisher LC, Fait DL, Savine TA, Dodd DE, Klonne DR, Pritts IM
Year:
1995
Bibliographic source:
Fundamental and Applied Toxicology 24: 57-75
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Principles of method if other than guideline:
LC50 value derived from teratogenicity study.
GLP compliance:
yes
Test type:
other: LC50 value derived from teratogenicity study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethane-1,2-diol
EC Number:
203-473-3
EC Name:
Ethane-1,2-diol
Cas Number:
107-21-1
Molecular formula:
C2H6O2
IUPAC Name:
ethane-1,2-diol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
see 7.8.2 Developmental toxicity / teratogenicity

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Details on inhalation exposure:
see 7.8.2 Developmental toxicity / teratogenicity
Duration of exposure:
6 h
Concentrations:
60, 400 or 1000 ppm
150, 1000 or 2500 mg/m3 (0.15, 1.00 or 2.5 mg/L)
No. of animals per sex per dose:
see 7.8.2 Developmental toxicity / teratogenicity
Control animals:
yes
Details on study design:
see 7.8.2 Developmental toxicity / teratogenicity
Statistics:
see 7.8.2 Developmental toxicity / teratogenicity

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.5 mg/L air
Based on:
test mat.
Exp. duration:
6 h

Applicant's summary and conclusion