Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Assessment of the Developmental Toxicity of Ethylene Glycol Applied Cutaneously to CD-1 Mice.
Author:
Tyl RW, Fisher LC, Kubena MF, Vrbanic MA, Losco PE
Year:
1995
Bibliographic source:
Fundamental and Applied Toxicology 27: 155-166
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Principles of method if other than guideline:
LD50 derived from developmental toxicity study.
GLP compliance:
yes
Test type:
other: LD50 derived from developmental toxicity study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethane-1,2-diol
EC Number:
203-473-3
EC Name:
Ethane-1,2-diol
Cas Number:
107-21-1
Molecular formula:
C2H6O2
IUPAC Name:
ethane-1,2-diol

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
see developmental toxicity/teratogenicity
Doses:
approx. 404, 1677 and 3549 mg/kg bw
No. of animals per sex per dose:
see developmental toxicity/teratogenicity
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 500 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met