Registration Dossier
Registration Dossier
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EC number: 204-065-8 | CAS number: 115-10-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Rapidly absorbed and distributed following exposure by inhalation. No bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - inhalation (%):
- 100
Additional information
DME is a gas and potential exposure would likely occur via the inhalation route. Therefore, no oral or dermal route absorptions are indicated. The absorption via inhalation involves passive diffusion until equilibrium is reached between partial DME pressure in the tissues and the air.
The toxicokinetics of DME in rats were evaluated following 1-h inhalation of 1000 ppm (1.9 mg/L) and 30 min to concentrations between 745 and 2000 ppm (between 1.4 and 3.8 mg/L) DME. Test substance concentrations were determined in rat blood, heart, lungs, liver, spleen, kidneys, fat, muscles and brain. The test substance was absorbed into blood and distributed widely to organs and tissues. The increases in test substance concentrations in these organs/tissues, including brain, were rapid and similar except for a slower increase in fat and muscles. Test substance concentrations in fat were approximately 30% higher than in other tissues. After a 1-h exposure to 1000 ppm, test substance levels decreased rapidly and equally (except for fat which was cleared slightly slower). Following a single short spraying application in humans, test substance concentrations in blood were low and decreased rapidly following the exposure.
It is concluded that the test substance is rapidly absorbed into the blood and tissues, is quickly eliminated once the exposure is terminated, and has a low bioaccumulation potential in rats and humans.
In comparing species, one should realize that reaching equilibrium between tissue concentration and the outside concentration in air takes time, which increases with increasing size of the organism. As a consequence, the duration of an internal peak concentration will be shorter in humans compared to rats, and possibly not even reaching the equilibrium level for the peak exposure when duration is relative short. The area under the curve will be the same, however, it is considered that effects by DME are driven by peak exposures.
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