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Diss Factsheets
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EC number: 203-615-4 | CAS number: 108-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Old publication, not according to any guidelines, poor description of the method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 955
- Report date:
- 1955
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test item was applied in the conjunctival sac of the left eyes to 2 groups of 3 albino rabbits each undiluted (30 mg of the dry powdered melamine) and as a 10 % suspension in a 0.5 % solution of methyl cellulose at a dosage of 0.05 cc . The eyes were held closed for approximately one minute. The right eyes served as control.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Melamine
- EC Number:
- 203-615-4
- EC Name:
- Melamine
- Cas Number:
- 108-78-1
- Molecular formula:
- C3H6N6
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triamine
- Details on test material:
- - Name of test material (as cited in study report): Melamine- Chemical name: 2,4,6-Triamino-1,3,5-triazine- Molecular formula (if other than submission substance): C3H6N6- Molecular weight (if other than submission substance): 126- Analytical purity: 99 % minimum- Stability under test conditions: Stable in aqueous solution and to moderate heating. Deammonation occurs when heated above melting point. (350 ° C).
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- other: Undiluted and as a 10 % suspension in 0.5 % methyl cellulose solution.
- Controls:
- no
- Duration of treatment / exposure:
- 1 minute
- Observation period (in vivo):
- Maximum of 10 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Verbal; before the Draize scheme.
- Basis:
- animal: each
- Time point:
- other: each
- Remarks on result:
- other: See remarks.
- Remarks:
- Administration of the undiluted test item: The observation immediately after application showed the treated eyes of all three rabbits to be moderately irritated, subsiding to mildness at the one and four-hour observation period. Normal appearing of all three animals after 24 hours and continued so throughout the observation period. Administration of the 10 % suspension in a 0.5 % solution of methyl cellulose: No noticeable irritation observed at any time.
- Other effects:
- No gross pathology was observed when the animals were sacrificed.
Any other information on results incl. tables
Administration of the undiluted test item: The observation immediately after application showed the treated eyes of all three rabbits to be moderately irritated, subsiding to mildness at the one and four-hour observation period. Normal appearing of all three animals after 24 hours and continued so throughout the observation period.
Administration of the 10 % suspension in a 0.5 % solution of methyl cellulose: No noticeable irritation observed at any time.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Three study results are available, Hofmann 1969, Shaffer 1955 and Marhold 1972. Two rather old studies, Hofmann 1969 and Shaffer 1955, are used in a weight of evidence approach. Consistent results are reported. These 2 studies do not meet fully the current guidelines (e.g. only 30 or 50 mg test substance were instilled), but they are considered to be adequate for the purpose of classification and for coverage of the key parameters foreseen to be investigated in the corresponding test methods. The third study is considered to be unreliable.
- Executive summary:
When a 30 mg dose of the dry powdered melamine was placed in the conjunctival sac of the left eyes of albino rabbits there was some irritation in all animals immediately, disappearing within 24 hours, and the eyes then remained normal for the duration of the observation.
When a 10 % suspension of melamine in a 0.5 % methyl cellulose solution was applied in 0.05 cc doses to the eyes of albino rabbits, no irritation was noted at any time during the observation period.
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