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Registration Dossier
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EC number: 203-398-6 | CAS number: 106-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study, no single isomer examined but a m/p-mixture
Data source
Reference
- Reference Type:
- publication
- Title:
- Quantitative analysis of cresol and ists metabolites in biological materials and distribution in rats after orál administration
- Author:
- Morinaga Y, Fuke Ch, Arao T, Miyazaki T
- Year:
- 2 004
- Bibliographic source:
- Legal Med 6, 32-40
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- oral application of a cresol soap solution to male rats via gastric tube and examination of cresol content in various tissues at various time points as well as the analysis of the respective glucuronides and sulfates.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- cresol soap solution containing 200 mg/ml p-cresol and 320 mg/ml m-cresol
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: average weight 410 g
- Fasting period before study: 24 hours
- Diet : ad libitum
- Water :ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
the with water diluted cresol soap solution of which amounts were 2.5 ml/kg (100 mg p-cresol and 160 mg m-cresol) - Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see above
- No. of animals per sex per dose / concentration:
- no data on number of male rats
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- see section " additional information on material and method"
- Details on dosing and sampling:
- see section " additional information on material and method"
- Statistics:
- see section " additional information on material and method"
Results and discussion
- Preliminary studies:
- see section "remarks on results"
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- see section "remarks on results"
- Details on distribution in tissues:
- see section "remarks on results"
- Details on excretion:
- see section "remarks on results"
Metabolite characterisation studies
- Details on metabolites:
- see section "remarks on results"
Any other information on results incl. tables
p-cresol administered by gavage to male Wistar rats were detected in blood and distributed to the brain, kidney, liver, lung, muscle, and spleen. The unconjugated p-cresol as well as the glucuronide and sulfate metabolites were eliminated from blood, brain, lung, muscle, liver, spleen, and kidneys for the most part within several hours.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results.
- Executive summary:
Oral application of a cresol soap solution containing m- and p-cresol to Wistar rats was readily absorbed, distributed in liver, spleen and kidney and excreted as sulfate or glucuronide.
p-cresol administered by gavage to male Wistar rats were detected in blood and distributed to the brain, kidney, liver, lung, muscle, and spleen. The unconjugated p-cresol as well as the glucuronide and sulfate metabolites were eliminated from blood, brain, lung, muscle, liver, spleen, and kidneys for the most part within several hours.
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