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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature: experimental details are missing, only one dose used

Data source

Reference
Reference Type:
review article or handbook
Title:
Inhalational effect of cresol isomers at low concentrations and means for improving detoxication processes in experiments on white rats
Author:
Pereima VL
Year:
1975
Bibliographic source:
Dissertation, Lvov, pp. 86-90, cited in: IPCS (1995), Environmental Health Criteria Report No. 168 : Cresols, International Programme on Chemical Safety

Materials and methods

Principles of method if other than guideline:
Rats were exposed by inhalation to p-cresol.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-cresol
EC Number:
203-398-6
EC Name:
p-cresol
Cas Number:
106-44-5
Molecular formula:
C7H8O
IUPAC Name:
p-cresol
Details on test material:
Test substance: p-cresol, purity not noted

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: no data
Duration of treatment / exposure:
4 months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01 mg/l
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: 2 months

Results and discussion

Effect levels

Dose descriptor:
LOAEL
Effect level:
0.01 other: mg/l
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on the nose, eye and skin. Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. Throughout recovery the body weights remained depressed and urinary excretion remained low.

Applicant's summary and conclusion

Executive summary:

Female rats were exposed to p-cresol aerosols. Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on the nose, eye and skin. Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. Throughout recovery the body weights remained depressed and urinary excretion remained low.