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EC number: 941-364-9 | CAS number: -
Skin and eye irritation studies on samples of diesel fuel were identified. The material was considered irritating to the skin but was not irritating to the eye.
Primary dermal irritation score: 6.81
In an skin irritation study, 3 male and 3 female New Zealand White rabbits were exposed to diesel fuel (market place sample). Before test material application, each animals was clipped of hair in an area from the shoulders to the hips and halfway down either side of the thorax. There were four exposure sites per animals (2 on each side of the midline). On the day of the study, the left posterior and right anterior site on each animal was abraded. Incisions penetrated the stratum corneum, but not the dermis. The remaining test sites were left in tact. 0.5 mL of test material was applied to gauze patches backed by plastic wrap. The patches were applied to the four test sites and were secured in place with bandage strips and elastic tape. After 24 hours, the wrapping and patches were removed. Excess test material was removed by wiping the skin with gauze sponges. Observations for erythema and oedema were recorded at 24 and 72 hours, and 7 and 14 days post-application. Erythema and oedema were scored using the Draize method.
At 24 hours the test sites were very irritated. Blisters formed, some open and with skin peeled back. At 72 hours, the sites remained very irritated, two rabbits had open sores. By day 7 most of the sites had formed scabs. By the 14th day, the skin was healing, but still dry and flaky with no hair growth on the test sites. The mean erythema and oedema scores for 24 and 72 hours are 3.9 and 2.96, respectively. Diesel fuel is classified as an irritant.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
In an eye irritation study, four females and five males were administered 0.1 mL of undiluted #2 home heating oil. The test material was applied to the everted lower lid of the right eye of each of the nine rabbits. The left eye served as the untreated control. In one male and one female, the test eye was flushed for one minute with distilled warm water 30 seconds after application. Ocular lesions were scored at 24, 48, and 72 hours after treatment. Fluorescein dye evaluation was used for the 24 hour scoring. Scoring was based on the Draize technique.
Only one rabbit, in the unrinsed group, exhibited minor conjunctival erythema at the 24 and 48 hour reading. All other animals were normal. Under the conditions of this study and according to EU regulations, the test material is not irritating to eyes.
This study received a Klimisch score of 1. It is classified as reliable without restrictions because it was conducted similar to guideline study OECD 405. .
The results of the skin irritation study in rabbits meet the criteria for classification as a skin irritant.
The level of reaction in the eye irritation study did not meet the criteria for classification.
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