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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Long term toxicity effect of test chemical on freshwater daphnia magna were studied for 21 days.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia sp.
Details on test organisms:
- Common name: Water flea
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.619 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Neutral Organic SAR
Validity criteria fulfilled:
no
Conclusions:
After the exposure of test chemical with daphnia for 21 days, no effcet were observed at 0.619 mg/l.
Executive summary:

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.619 mg/l for invertebrate daphnia for 21 d duration. Based on the NOEC value, chemical consider to be toxic and classified sa aquatic chronic 2 as per the CLP classification criteria.

Description of key information

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.619 mg/l for invertebrate daphnia for 21 d duration. Based on the NOEC value, chemical consider to be toxic and classified sa aquatic chronic 2 as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.619 mg/L

Additional information

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.619 mg/l for invertebrate daphnia for 21 d duration. Based on the NOEC value, chemical consider to be toxic and classified sa aquatic chronic 2 as per the CLP classification criteria.