Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Dose No.: B244
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):Furia, T. E. (Ed.) CRC Handbook of Food Additives 2nd ed., 1972, Chemical Rubber Co., Cleveland, OH.
- Reference Type:
- other: Authoritative data base
- Title:
- NTP study for 25013-16-5
- Author:
- NTP Database
- Year:
- 2 012
- Bibliographic source:
- NTP (National Toxicological Program)by Agency for Toxic Substances and Disease Registry; Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, Georgia 30333
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from NTP database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg of tert-butyl-4-methoxyphenol (BHA)
- Control animals:
- not specified
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- 27-77% was excreted in the urine
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- 27-77% was excreted in the urine as the glucuronide and urinary metabolites.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- glucuronide and urinary metabolites.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
When male human volunteers were given an oral dose of 50 mg tert-butyl-4-methoxyphenol (BHA), 27-77% was excreted in the urine as the glucuronide and urinary metabolites. - Executive summary:
When male human volunteers were given an oral dose of 50 mg tert-butyl-4-methoxyphenol (BHA), 27-77% was excreted in the urine as the glucuronide and urinary metabolites.
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