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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number : SL1945000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):TRENAF Kenkyu Nenpo- Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. V.1- 1949/50- Volume(issue)/page/year: 22,231,1970
Reference Type:
review article or handbook
Title:
DPIM : BQI000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials) : Kenkyu Nenpo-Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. 22 (1970), 231.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-tert-butyl-4-methoxyphenol
EC Number:
204-442-7
EC Name:
2-tert-butyl-4-methoxyphenol
Cas Number:
121-00-6
Molecular formula:
C11H16O2
IUPAC Name:
2-tert-butyl-4-methoxyphenol
Details on test material:
- Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
Mortality:
Lethal dose, 50 percent kill
Clinical signs:
other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.
Executive summary:

The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.