Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : SL1945000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):TRENAF Kenkyu Nenpo- Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. V.1- 1949/50- Volume(issue)/page/year: 22,231,1970
- Reference Type:
- review article or handbook
- Title:
- DPIM : BQI000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Kenkyu Nenpo-Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. 22 (1970), 231.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- Mortality:
- Lethal dose, 50 percent kill
- Clinical signs:
- other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.
- Executive summary:
The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.
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