Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative Report
- Title:
- Inert Ingredient Reassessment - Butylated Hydroxyanisole (250 13- 16-5)
- Author:
- Pauline Wagner
- Year:
- 2 005
- Bibliographic source:
- UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, WASHINGTON, D.C. 20460; (CIR 1984)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data from USEPA report
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- other: eye makeup preparation containing 0.1% BHA
Any other information on results incl. tables
Acute dermal testing rabbits of an eye makeup preparation containing 0.1% BHA yielded an LD50 > 2000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the LD50 value of >2000 mg/kg for rabbit avaialble for tert-butyl-4-methoxyphenol, tt can be concluded that tert-butyl-4-methoxyphenol is not toxic via dermal route
- Executive summary:
Based on the LD50 value of >2000 mg/kg for rabbit avaialble for tert-butyl-4-methoxyphenol, it can be concluded that tert-butyl-4-methoxyphenol is not toxic via dermal route
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