Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: SL1945000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances) : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 27,15,1985
Reference Type:
review article or handbook
Title:
Dose No.: B244
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE); : Toxicol. Lett. 1985, 27, 15.
Reference Type:
other: Authoritative data base
Title:
HSDB Number : 3913
Author:
HSDB Database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Available at: http://monographs.iarc.fr/index.php, p. V40 135 (1986)
Reference Type:
review article or handbook
Title:
DPIM : BQI000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials) : Toxicology Letters. 27 (1985), 15.
Reference Type:
review article or handbook
Title:
SciFInder ID : 116
Author:
Takahashi, O.
Year:
2011
Bibliographic source:
SciFInder, American Chemical Society (ACS); : Takahashi, O.; Toxicology Letters 1985, V27(1-3), P15-25 CAPLUS

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS,DOSE,HSDB,SAX,SciFinder database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
881 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Toxic Effect : Blood - hemorrhage
Mortality:
Lethal dose ; 50 percent kill
Clinical signs:
Toxic Effect : Blood - hemorrhage

Applicant's summary and conclusion

Conclusions:
Intraperitoneal toxicity of tert-butyl-4-methoxyphenol to rat was examined at dose concentration of 881 mg/kg of body weight.
Executive summary:

Intraperitoneal toxicity oftert-butyl-4-methoxyphenolto rat was examined at dose concentration of 881 mg/kg of body weight.