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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Final Report on the Safety Assessment of Butylated Hydroxyanisole
Year:
1984
Bibliographic source:
International Journal of Toxicology September/October 1984 3: 83-146,

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from International Journal of Toxicology
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-tert-butyl-4-methoxyphenol
EC Number:
204-442-7
EC Name:
2-tert-butyl-4-methoxyphenol
Cas Number:
121-00-6
Molecular formula:
C11H16O2
IUPAC Name:
2-tert-butyl-4-methoxyphenol
Details on test material:
- Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits. and it can be concluded the the tert-butyl-4-methoxyphenol is not irritating to skin based on not sufficient infromation available for classification as the per the CLP criteria.
Executive summary:

Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits. and it can be concluded the the tert-butyl-4-methoxyphenol is not irritating to skin based on not sufficient infromation available for classification as the per the CLP criteria.

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