Registration Dossier
Registration Dossier
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EC number: 229-347-8 | CAS number: 6484-52-2
Endpoint summary
Administrative data
Description of key information
Exposure-related observations were described in several reports. These reports showed that after ingestion of ammonium nitrate no occurrences of severe toxicity were observed. Also no measurable hematological effect, elevation of methemoglobin or circulating N-nitroso compounds were observed.
Additional information
- No significant excess was observed for all causes of mortality or for mortality from any of five broad categories of cause or from four specific types of cancer. This was true for the entire cohort as well as for a subgroup that had been heavily exposed to nitrates.
- Direct ingestion of ammonium nitrate cold packs resulted in no occurrences of severe toxicity, although some patients experienced symptoms of gastritis, slight methemoglobinemia, and mild hypertension.
- No measurable hematological effect, elevation of methemoglobin or circulating N-nitroso compounds were observed. Also, no volatile N-nitrosamines were detected in the blood.
- There is no evidence that methaemoglobinaemia is caused by bacterially sound water supplies at concentrations up to 100 mg nitrate.
- Twelve humans resulted in an average urinary nitrate excretion of 75% within 24 h, with small amounts of nitrite detected in only 26% of the samples. Nitrate baseline levels in urine were 149-577 mg/L.
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