Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

exposure-related observations in humans: other data
Adequacy of study:
supporting study
other: no data

Data source

Reference Type:
Mortality of nitrate fertilizer workers
Al-Dabbagh, S., Forman, D., Bryson, D., Stratton, I., and Doll, R.
Bibliographic source:
British Journal of Industrial Medicine. 43:507-515.

Materials and methods

Type of study / information:
no data
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
nitrates (fertilizer)
nitrates (fertilizer)
Details on test material:
no data


Details on study design:
no data
Exposure assessment:
not specified

Results and discussion

No significant excess was observed for all causes of mortality or for mortality from any of five broad categories of cause or from four specific types of cancer. This was true for the entire cohort as well as for a subgroup that had been heavily exposed to nitrates.

Any other information on results incl. tables

A total of 1327 male workers engaged in the production of nitrate based fertilizers between 1946 and 1981 were tracked until 1981. In addition, a subgroup consisting of workers heavily exposed to nitrate, defined as working in an environment likely to contain more than 10 mg NO3/m3for a year or longer, was separately analyzed.

Applicant's summary and conclusion