Registration Dossier
Registration Dossier
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EC number: 931-534-0 | CAS number: 68439-57-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Environmental and human safety of major surfactants. Volume 1. Anionic surfactants. Part 4. Alpha olefin sulfonates
- Author:
- Little, A.D.
- Year:
- 1 993
- Bibliographic source:
- National Technical Service (NTIS) report No. PB94-102423
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- limited documentation in review article
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- EC Number:
- 931-534-0
- Cas Number:
- 68439-57-6
- Molecular formula:
- C(4+2n)H(9+4n)SO4Na C(4+2n)H(7+4n)SO4Na n = 5-6
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
- Details on test material:
- - Name of test material (as cited in study report): C14-C16 AOS
- Analytical purity: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- TEST ATMOSPHERE (if not tabulated)
- Information on particle size for either treatment was unavailable
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- - 90% active of powdered aerosol of C14-C16 AOS flake at a concentration of 229mg/L
- 17% active of powdered aerosol of spray dried formulation of C14-C16 AOS at a concentration of 221mg/L - No. of animals per sex per dose:
- 10 rats, no sex specified
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes, immediately after exposure 5 rats from each group and from the remaining animals after a 14 day observation period
- Other examinations performed: gross pathological changes
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 52 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 4 h
- Remarks on result:
- other: converted from 1h to 4h exposure based on Haber's law and guidance of CLP regulation
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 206 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 1 h
- Remarks on result:
- other: recalculated to active ingredient
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 229 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- no mortalities reported
- Clinical signs:
- other: indistinguishable from controls
- Body weight:
- indistinguishable from controls
- Gross pathology:
- Mild petechial hemorrhage of the lungs was noted in two animals exposed to the AOS flake and one animal exposed to the spray-dried formulation
Any other information on results incl. tables
When administered as an aerosol with 90% active ingredient to rats for 1h the LC50 for C14 -C16 AOS is >229mg/L. Based on Haber's law this can be converted to an LC50 of >52mg/L for a 4h exposure to neat substance (see "Guidance on the Application of the CLP Criteria" p.194).
According to DSD and CLP the test substance does not have to be classified for inhalation toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- EU Directive 67/548/EEC: not classified
Regulation (EC) No 1272/2008: not classified
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