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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other: substantially saturated vapor
GLP compliance:
no
Test type:
other: substantially saturated vapour
Limit test:
no

Test material

Constituent 1

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Substantially saturated vapor was prepared by spreading 50 grams of chemical over 200 cm(2) area on shallow tray placed near the top of a 120-litre glass chamber which was then sealed for at least 16 hours while an intermittently operated fan agitated the internal chamber atmosphere. 
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
Rats introduced in a gasketed drawer-type cage designed and operated to minimize vapor loss. The study was conducted at 20°C. The animals were observed for 14 days postexposure for signs of toxicity.
Statistics:
Not applicable.

Results and discussion

Effect levels
Remarks on result:
other: Exposure to substantially saturated vapor for 8 hours caused no mortality.
Mortality:
Exposure to substantially saturated vapor for 8 hours caused no mortality.
Clinical signs:
other: No signs and/or symptoms were reported.
Body weight:
Weight change over the 14-day postexposure period ranged from 51 to 71 grams.  

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The findings of a 8-hr exposure to substantially saturated vapour of (3-chloropropyl)trimethoxysilane indicate a low potential for toxicity by acute inhalation exposure.