Registration Dossier
Registration Dossier
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EC number: 220-552-8 | CAS number: 2809-21-4
Endpoint summary
Administrative data
Description of key information
The substance is of low short-term toxicity to fish with key values of 96 hour LC50 195 mg/L tested with HEDP-H on Oncoryhnchus mykiss (ABC, 1979) and 96 hour LC50 2180 mg/L tested with HEDP-H on Cyprinodon variegatus (EG&G, 1976).
A 14 day NOEC value of 60 mg/L (as active acid) has been determined for the effects of HEDP-H on the altered behaviour and loss of equilibrium of the freshwater fish Salmo gairdneri (now known as Oncorhynchus mykiss) (ABC, 1979). There are no true long-term toxicity to fish studies with the registration substance and this endpoint has been waived.
The registration substance is of low short-term toxicity to invertebrates with key values of 48 hour EC50 527 mg/L with D. magna as HEDP-H (Monsanto, 1981) and a 96 hour LC50 1770 mg/L with P. pugio as HEDP-H (EG&G, 1976).
A 28 day NOEC value of 6.75 mg/L has been determined for the effects of HEDP-H on adult mortality and offspring production of the freshwater invertebrate Daphnia magna (Monsanto, 1976).
The algal inhibition study has been waived on the basis that:
In accordance with Section 2 of REACH Annex XI, the study does not need to be conducted because an assessment of the toxicity to aquatic algae and cyanobacteria is technically not possible due to substances complexing properties of essential nutrients present in the test media.
A weight of evidence approach is used for aquatic microbial inhibition studies. The available data supports a conclusion of an EC0 value of at least 200 mg active acid/L in aerobic and anaerobic microorganisms under prolonged exposure in STP simulation tests.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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