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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a summary report was available for review.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Similar to standard acute toxicity test.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Etidronic acid
EC Number:
220-552-8
EC Name:
Etidronic acid
Cas Number:
2809-21-4
Molecular formula:
C2H8O7P2
IUPAC Name:
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
Details on test material:
- Name of test material (as cited in study report): HEDP-4-hydrat (described as a solution at pH5, so it is not clear whether the test substance is in fact a sodium salt.
No further details available.

Test animals

Species:
mouse
Strain:
other: StammCF w168
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
158, 199, 251, 316 and 398 mg/kg bw
No. of animals per sex per dose:
10 males
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
285 mg/kg bw
95% CL:
>= 239 - <= 339

Applicant's summary and conclusion

Conclusions:
In an intraperitoneal acute toxicity study (reliability score 4) only available as a summary, the LD50 for HEDP-4-hydrat was 285 mg/kg bw in mice.

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