Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 468-710-7 | CAS number: 754-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Uses by professional workers
Documentsopen allclose all
Uses by professional workers
Contributing activity / technique for the environment
- Name of activity / technique:
- Heat transfer fluids – Refrigerants, coolants
- Environmental release category (ERC):
- ERC9b: Widespread use of functional fluid (outdoor)
Contributing activity / technique for workers
- Name of activity / technique:
- Heat transfer fluids – Refrigerants, coolants
- Process category (PROC):
- PROC 8b: Transfer of substance or mixture (charging and discharging) at dedicated facilities
- Product category used:
- PC 16: Heat transfer fluids
- Sector of end use:
- SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment
- Substance supplied to that use in form of:
- as such
- in a mixture
- Subsequent service life relevant to this use:
- yes
- Related assessment:
- use assessed in an own CSR
Uses by professional workers
- Registration/ Notification status for the use:
- use registered according to REACH Article 10; total tonnage manufactured/imported >=10tonnes/year per registrant
Contributing activity / technique for the environment
- Name of activity / technique:
- Professional end-use: installation and servicing / maintenance of air conditioning systems
- Environmental release category (ERC):
- ERC9a: Widespread use of functional fluid (indoor)
- ERC9b: Widespread use of functional fluid (outdoor)
Contributing activity / technique for workersopen allclose all
- Name of activity / technique:
- Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Process category (PROC):
- PROC 8a: Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Name of activity / technique:
- Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities
- Process category (PROC):
- PROC 8b: Transfer of substance or mixture (charging and discharging) at dedicated facilities
- Product category used:
- PC 16: Heat transfer fluids
- Sector of end use:
- SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment
- Substance supplied to that use in form of:
- in a mixture
- Subsequent service life relevant to this use:
- yes
- Related assessment:
- use assessed in an own CSR
Contributing scenario for the environment (related to workers activities)
Conditions of use for the environment
Amounts used, frequency and duration of use (or from service life)
Other conditions
Technical and organisational conditions and measures
Other technical and organisational conditions
Conditions and measures related to Biological Sewage Treatment Plant
- Biological Sewage Treatment Plant (STP):
- municipal biological STP
Conditions and measures related to external treatment of waste (including article waste)
- Particular considerations on the waste treatment operations:
- treatment under rigorous containment conditions required
Releases to waste and the environment
Release to the environment
ReleaseEnvirRepopen allclose all
- Release from the site to::
- wastewater
- Release estimation method:
- estimated release factor
- Remarks:
- Process and substance knowledge
- Release from the site to::
- ambient air
- Release estimation method:
- estimated release factor
- Remarks:
- ESVOC SPERC9.13b.v2
- Release from the site to::
- non-agricultural soil
- Release estimation method:
- estimated release factor
- Remarks:
- Process and substance knowledge
Exposure of the environment
PECopen allclose all
- Exposed compartment:
- freshwater
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sediment (freshwater)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- marine water
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sediment (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sewage treatment plant
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- air
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- agricultural soil
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (freshwater)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- top predators' prey (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (terrestrial)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
Exposure of humans via the environment
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
ContribScenWorkersRepopen allclose all
Contributing scenario for the workers
Conditions of use for workers
Product (article) characteristics
- Physical form of the used product:
- liquefied gas
Amounts used (or contained in articles), frequency and duration of use/exposure
OtherConditionsRepopen allclose all
Technical and organisational conditions and measures
TechCondRepopen allclose all
Conditions and measures related to personal protection, hygiene and health evaluation
PPERepopen allclose all
Other conditions affecting workers exposure
- Place of use:
- indoor
Exposure of workers
ExpEstopen allclose all
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- measured data
- Exposure estimation tool name:
- other: Gjolstad et al., 2003; refrigeration repair workers’ data generated on HFC-134a
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- ECETOC TRA workers
Contributing scenario for the workers
Conditions of use for workers
Product (article) characteristics
- Physical form of the used product:
- liquefied gas
Amounts used (or contained in articles), frequency and duration of use/exposure
OtherConditionsRepopen allclose all
Technical and organisational conditions and measures
TechCondRepopen allclose all
Conditions and measures related to personal protection, hygiene and health evaluation
PPERepopen allclose all
Other conditions affecting workers exposure
- Place of use:
- indoor
Exposure of workers
ExpEstopen allclose all
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- measured data
- Exposure estimation tool name:
- other: Gjolstad et al., 2003; refrigeration repair workers’ data generated on HFC-134a
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- ECETOC TRA workers
Uses by professional workers
- Registration/ Notification status for the use:
- use registered according to REACH Article 10; total tonnage manufactured/imported >=10tonnes/year per registrant
Contributing activity / technique for the environment
- Name of activity / technique:
- Professional end-use: installation and servicing / maintenance of air conditioning systems
- Environmental release category (ERC):
- ERC9a: Widespread use of functional fluid (indoor)
- ERC9b: Widespread use of functional fluid (outdoor)
Contributing activity / technique for workersopen allclose all
- Name of activity / technique:
- Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Process category (PROC):
- PROC 8a: Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Name of activity / technique:
- Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities
- Process category (PROC):
- PROC 8b: Transfer of substance or mixture (charging and discharging) at dedicated facilities
- Product category used:
- PC 16: Heat transfer fluids
- Sector of end use:
- SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment
- Substance supplied to that use in form of:
- in a mixture
- Subsequent service life relevant to this use:
- yes
- Related assessment:
- use assessed in an own CSR
Contributing scenario for the environment (related to workers activities)
Conditions of use for the environment
Amounts used, frequency and duration of use (or from service life)
Other conditions
Technical and organisational conditions and measures
Other technical and organisational conditions
Conditions and measures related to Biological Sewage Treatment Plant
- Biological Sewage Treatment Plant (STP):
- municipal biological STP
Conditions and measures related to external treatment of waste (including article waste)
- Particular considerations on the waste treatment operations:
- treatment under rigorous containment conditions required
Releases to waste and the environment
Release to the environment
ReleaseEnvirRepopen allclose all
- Release from the site to::
- wastewater
- Release estimation method:
- estimated release factor
- Remarks:
- Process and substance knowledge
- Release from the site to::
- ambient air
- Release estimation method:
- estimated release factor
- Remarks:
- ESVOC SPERC9.13b.v2
- Release from the site to::
- non-agricultural soil
- Release estimation method:
- estimated release factor
- Remarks:
- Process and substance knowledge
Exposure of the environment
PECopen allclose all
- Exposed compartment:
- freshwater
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sediment (freshwater)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- marine water
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sediment (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- sewage treatment plant
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- air
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- agricultural soil
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (freshwater)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- top predators' prey (marine water)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
- Exposed compartment:
- predators' prey (terrestrial)
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
Exposure of humans via the environment
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- EUSES
ContribScenWorkersRepopen allclose all
Contributing scenario for the workers
Conditions of use for workers
Product (article) characteristics
- Physical form of the used product:
- liquefied gas
Amounts used (or contained in articles), frequency and duration of use/exposure
OtherConditionsRepopen allclose all
Technical and organisational conditions and measures
TechCondRepopen allclose all
Conditions and measures related to personal protection, hygiene and health evaluation
PPERepopen allclose all
Other conditions affecting workers exposure
- Place of use:
- indoor
Exposure of workers
ExpEstopen allclose all
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- measured data
- Exposure estimation tool name:
- other: Gjolstad et al., 2003; refrigeration repair workers’ data generated on HFC-134a
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- ECETOC TRA workers
Contributing scenario for the workers
Conditions of use for workers
Product (article) characteristics
- Physical form of the used product:
- liquefied gas
Amounts used (or contained in articles), frequency and duration of use/exposure
OtherConditionsRepopen allclose all
Technical and organisational conditions and measures
TechCondRepopen allclose all
Conditions and measures related to personal protection, hygiene and health evaluation
PPERepopen allclose all
Other conditions affecting workers exposure
- Place of use:
- indoor
Exposure of workers
ExpEstopen allclose all
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- measured data
- Exposure estimation tool name:
- other: Gjolstad et al., 2003; refrigeration repair workers’ data generated on HFC-134a
- Type of exposure:
- inhalation (external) long-term exposure
- Exposure estimation method:
- exposure estimation tool
- Exposure estimation tool name:
- ECETOC TRA workers
Uses by professional workers
Contributing activity / technique for the environment
- Environmental release category (ERC):
- ERC9a: Widespread use of functional fluid (indoor)
- ERC9b: Widespread use of functional fluid (outdoor)
Contributing activity / technique for workers
- Process category (PROC):
- PROC 8a: Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Product category used:
- PC 16: Heat transfer fluids
- Sector of end use:
- SU 0: Other: SU 22: Professional uses: Public domain (administration, education, entertainment, services, craftsmen)
- Substance supplied to that use in form of:
- as such
- in a mixture
- Subsequent service life relevant to this use:
- yes
- Related assessment:
- use assessed in an own CSR
Uses by professional workers
Contributing activity / technique for the environment
- Environmental release category (ERC):
- ERC9a: Widespread use of functional fluid (indoor)
- ERC9b: Widespread use of functional fluid (outdoor)
Contributing activity / technique for workers
- Process category (PROC):
- PROC 8a: Transfer of substance or mixture (charging and discharging) at non-dedicated facilities
- Product category used:
- PC 16: Heat transfer fluids
- Substance supplied to that use in form of:
- as such
- in a mixture
- Subsequent service life relevant to this use:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.