Registration Dossier
Registration Dossier
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EC number: 468-710-7 | CAS number: 754-12-1
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2008
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- -
- EC Number:
- 468-710-7
- EC Name:
- -
- Cas Number:
- 754-12-1
- Molecular formula:
- C3H2F4
- IUPAC Name:
- 2,3,3,3-tetrafluoroprop-1-ene
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 30 °C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: 515 HPLC Pump, 717 Plus Autosampler (Waters, Milford, MA, USA)
- Type, material and dimension of analytical (guard) column: Hypersil BDS-CN, 150 x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
- Detection system: Photodiode Array Dectector 2996, UV dectection at 210 nm (Waters, Milford, MA, USA), Refractive Index Detector 2414, sensitivity = 4, time constant = 1 sec (Waters, Milford, MA, USA)
MOBILE PHASES
- Type: 55/45 (v/v) Methanol/Water
- Experiments with additives carried out on separate columns: no
- Solutes for dissolving test and reference substances: Methanol
REFERENCE SUBSTANCES
- Identity: Acetanilide
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µl
- Quantity of reference substances: 10 µl
REPETITIONS
- Number of determinations: 2
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- < 18
- Type:
- log Koc
- Value:
- < 1.26
Results: HPLC method
- Details on results (HPLC method):
- UV detection
- Retention times of reference substances used for calibration: Acetanilide: 2.23 min (Log Koc: 1.26)
- Retention time of test Substance: 1.91 min
RI detection
- Retention times of reference substances used for calibration: Acetanilide: 2.46 min (Log Koc: 1.26)
- Retention time of test Substance: 2.14 min
It was concluded that the log Koc of the test substance was <1.26 (Koc <18)
Applicant's summary and conclusion
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