Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted under GLP conditions using methodology that is well accepted by organization responsible for fluorochemicals

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Cardiac sensitization was considered to have occurred if the response to epinephrine was enhanced following administration of the test article.

GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
754-12-1
Cas Number:
754-12-1
IUPAC Name:
754-12-1

Results and discussion

Any other information on results incl. tables

All animals survived to study termination. There were no test article-related clinical observations. Body weights were unaffected by test article administration. No cardiac sensitization was observed in any animal.

Applicant's summary and conclusion

Conclusions:
Cardiac sensitization to epinephrine was not observed in dogs exposed by inhalation to the test substance up to a level of 120000 ppm (559200 mg/m3; highest dose tested).