Polyhaloalkene

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted under GLP conditions using methodology that is well accepted by organization responsible for fluorochemicals

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Cardiac sensitization was considered to have occurred if the response to epinephrine was enhanced following administration of the test article.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

754-12-1

Cas Number:

754-12-1

IUPAC Name:

754-12-1

Results and discussion

Any other information on results incl. tables

All animals survived to study termination. There were no test article-related clinical observations. Body weights were unaffected by test article administration. No cardiac sensitization was observed in any animal.

Applicant's summary and conclusion

Conclusions:

Cardiac sensitization to epinephrine was not observed in dogs exposed by inhalation to the test substance up to a level of 120000 ppm (559200 mg/m3; highest dose tested).