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EC number: 468-710-7 | CAS number: 754-12-1
In all rat urine samples, the predominant metabolites were two diastereomers of N-Acetyl-S-(3,3,3-trifluoro-2-hydroxy-propyl)-L-cysteine. In 19F-NMR, the signal intensity of these metabolites represented more than 85% (50000 ppm) of total 19F related signals in the urine samples. Trifluoroacetic acid, 3,3,3-trifluorolactic acid, 3,3,3- trifluoro-1-hydroxyacetone, 3,3,3-trifluoroacetone and 3,3,3-trifluoro-1,2-dihydroxypropane were present as minor metabolites. Quantification of N-Acetyl-S-(3,3,3-trifluoro-2-hydroxypropyl)- L-cysteine by LC/MS-MS showed that most of this metabolite (90%) was excreted within 18 h after the end of exposure (t1/2 app. 6 h). In rats, the recovery of N-Acetyl-S- (3,3,3-trifluoro-2-hydroxy-propyl)-L-cysteine excreted within 48 h in urine was determined as 0.297 ± 0.028, 0.627 ± 0.155, and 2.432 ± 0.864 μmoles at 2000, 10000 and 50000 ppm, respectively suggesting only a low extent ( << 1% dose received) of biotransformation of test substance.
The very low extent of biotransformation following inhalation to high exposures of test substance indicates covalent binding resulting in potential liver toxicity is likely prevented by efficient detoxification by glutathione. These results are consistent with the lack of hepatotoxic in rats following 90 day inhalation exposure to test substance (see section 7.5 for details of this study).
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