Registration Dossier

Administrative data

Description of key information

No dedicated studies are available for the evaluation of the irritating potential of the test substance. However, no signs of eye, skin or respiratory irritation were observed in several inhalation toxicity studies. These include rabbits exposed by whole body for up to an hour at 100000 ppm (466000 mg/m3), rats exposed nose only for 4 hours up exposure concentrations up to 405000 (1907550 mg/m3), and rats (nose-only)  and rabbits (whole body) repeatedly exposed  to concentrations as high as 50000 ppm (233000 mg/m3).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no study available

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Irritation studies are no technically feasible because the substance is a gas at room temperature and ambient pressure. However, no signs of eye, skin or respiratory irritation were observed in several inhalation toxicity studies. These include rabbits exposed by whole body for up to an hour at 100000 ppm (466000 mg/m3), rats exposed nose only for 4 hours up exposure concentrations up to 405000 (1907550 mg/m3), and rats (nose-only) and rabbits (whole body) repeatedly exposed to concentrations as high as 50000 ppm (233000 mg/m3). Therefore classification and labelling for irritation/corrosion is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and its amendments.