MK1 Diesel Fuel

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable with restrictions because it is an acceptable and well-documented study report.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

64742-81-0

IUPAC Name:

64742-81-0

Constituent 2

Reference substance name:

straight run kerosine

IUPAC Name:

straight run kerosine

Test material form:

other: low viscosity liquid hydrocarbon

Details on test material:

Straight run kerosine (F-155)

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

5000 mg/kg

No. of animals per sex per dose:

five males and five females

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 other: mg/kg

Any other information on results incl. tables

There were no mortalities. All except one of the animals gained weight, the exception was an animal that had suffered mechanical injury which was not test-material-related. On or more of the following was observed in all animals: discharge (oral, nasal and/or ocular), abnormal stools, alopecia and/or stained coat. The only abnormality observed at necropsy was a deep purple colouration of the duodenum, ileum and jejunum of one animal.
The oral LD50 was greater than 5000 mg/kg.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Under the conditions of this study the LD50 is >5000 mg/kg.

Executive summary:

In an acute oral toxicity study, undiluted test material was administered at a dose of 5000 mg/kg by oral gavage to each of five male and five female Sprague-Dawley rats. Body weights were recorded just before and then seven and fourteen days following administration of test material. The animals were observed for clinical signs hourly for the first four hours after dosing and then twice daily for fourteen days. On day fourteen the surviving animals were killed and a gross necropsy was performed and any abnormalities were recorded.

There were no mortalities. All except one of the animals gained weight, the exception was an animal that had suffered mechanical injury which was not test-material-related. On or more of the following was observed in all animals: discharge (oral, nasal and/or ocular), abnormal stools, alopecia and/or stained coat. The only abnormality observed at necropsy was a deep purple colouration of the duodenum, ileum and jejunum of one animal.
The oral LD50 was greater than 5000 mg/kg.