Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data insufficient for assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Principles of method if other than guideline:
No guideline is specified and only limited details of the method are given in this brief report.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
no details
Observation period (in vivo):
no details, possibly 7 days
Number of animals or in vitro replicates:
no details

Results and discussion

In vivo

Results
Irritation parameter:
other: severe pain and tissue damage
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: The investigators suggest permanent injury is probable.

Any other information on results incl. tables

Treatment resulted in severe pain and tissue damage that did not subside within 7 days and was suggested to lead to permanent injury. The eyes were washed and unwashed - the effect of washing was not stated.

Applicant's summary and conclusion

Conclusions:
A very brief report of a possibly limited study found that the neat material (volume unspecified) applied to rabbit eyes caused severe pain and tissue damage that did not resolve within 7 days and was described as most likely leading to permanent injury