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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981-9-30 - 1981-10-22
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline compliant study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(diethylamino)ethyl methacrylate
EC Number:
203-275-7
EC Name:
2-(diethylamino)ethyl methacrylate
Cas Number:
105-16-8
Molecular formula:
C10H19NO2
IUPAC Name:
2-(diethylamino)ethyl methacrylate
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 7-8 weeks old
- Weight at study initiation: 230-270 g
- Fasting period before study:
- Housing: housed in pairs in stainless steal wire mesh cages
- Diet: Purino Rodent Chow #5002, ad libitum
- Water: ad libitum
- Acclimation period: 1 week

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:

TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
0.4, 0.7, 1.1, 1.4, 1.8 mg/L
No. of animals per sex per dose:
10 male animals per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
1.8 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
At concentrations groups 0.4 - 1.8 no mortality occurred. At the highest dose group, 1.8 mg/L, 7 out of 10 animals died.
Clinical signs:
other: During exposure: All rats exhibited a clear nasal and oral discharge. Rats exposed exposed to 0.7 mg/L or greater exhibited hyperplasia of the extremities. Rats exposed to 1.1. mg/L or greater exhibited labored breathing, sporadic tremors, and convulsions
Body weight:
Rats exposed to 0.4 mg/L exhibited slight weight loss but showed no adverse clinical signs. Rats exposed to higher concentrations exhibited slight to severe weight loss lasting 1 to 4 days post exposure, followed by the resumption of a normal rate of weight gain.
Gross pathology:
No data

Any other information on results incl. tables

An approximate lethal concentration of 1.8 mg/L was determined for the test substance.

Applicant's summary and conclusion