(2S)-[[(benzyloxy)carbonyl]amino](cyclohexyl)acetic acid

Explosiveness

Administrative data

Endpoint:

explosiveness

Type of information:

other: Theoretical assessment of the structure of the test substance

Adequacy of study:

supporting study

Study period:

Not applicable

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Although the testing facility indicated EU Method A14 was used, an experimental study using EU Method A14 was not conducted. Instead, a theoretical assessment of explosive properties of the test substance was conducted.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Deviations:

no

Remarks:

The testing facility indicated that the protocol was followed without deviations.

Principles of method if other than guideline:

Not applicable

GLP compliance:

no

Remarks:

Not applicable as theoretical assessment

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): VRT-126016
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): not applicable
- Substance type: no data
- Physical state: white to off-white powder
- Analytical purity: 99.8 area% by High Performance Liquid Chromatography (HPLC)
- Impurities: chloride: <0.1%
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: 2006-02-02
- Lot/batch No.: 25719
- Expiration date of the lot/batch: February 2008
- Stability under test conditions: no data
- Storage condition of test material: at room temperature
- Other: no data

Results and discussion

Small-scale preliminary tests

Small-scale preliminary tests 1

Parameter:

other: More sensitive to shock than m-dinitrobenzene

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 2

Parameter:

other: More sensitive to friction than m-dinitrobenzene

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 3

Parameter:

other: Explosive under influence of flame

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 4

Parameter:

other: Explosive (not specified)

Remarks:

migrated information

Remarks on result:

negative (not further specified)

Remarks:

: See "Remarks on results including tables and figures"

Any other information on results incl. tables

According to the United Nations Committee of Experts on the Transport of Dangerous Goods, explosive properties are associated with the presence of certain chemical groups in a molecule which can react to produce a very rapid increase in temperature or pressure. Thus, it is possible to examine the chemical structure of a substance and ascertain whether or not there are any groups present that are associated with explosive properties. For this purpose, a list of screening procedures has been published in Appendix 6 of the United Nations "Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria." The initial assessment of explosive properties is made by examining the chemical structures of the components with a list of functional groups that may indicate explosive properties in organic materials.

From an examination of the chemical structure of the test substance it was concluded that it contained no functional groups which are characteristic of explosive properties.

Applicant's summary and conclusion

Conclusions:

It was considered that the test substance was not explosive and therefore an assessment of this property was made using a theoretical assessment of the structure of the test substance.

Executive summary:

Not applicable