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Tetrahydromethylphthalic anhydride (MTHPA) is rapidly hydrolytically degraded in a few minutes and thoroughly hydrolyzed to the corresponding dicarboxylic acids. These hydrolysis products are not readily biodegraded.

Based on the physical/chemical parameters Tetrahydromethylphthalic anhydride (MTHPA) has a low potential for bioaccumulation and can be expected to have a low potential for adsorption (the substance has a low octanol water partition coefficient of 2.38-2.51 as calculated by EPIWIN).