Registration Dossier
Registration Dossier
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EC number: 234-290-7 | CAS number: 11070-44-3
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride
- Author:
- Jonsson, B. A. G.
- Year:
- 1 993
- Bibliographic source:
- Scand. J. Work Environ. Health,(1993) 19 183-190
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- respiratory sensitisation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No information on guideline. For details on method please refer to IUCLID5 dossier.
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexane-1,2-dicarboxylic anhydride
- EC Number:
- 201-604-9
- EC Name:
- Cyclohexane-1,2-dicarboxylic anhydride
- Cas Number:
- 85-42-7
- Molecular formula:
- C8H10O3
- IUPAC Name:
- 3a,4,5,6,7,7a-hexahydro-2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): HHPA
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- no details given
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: inhalation at the factory
TYPE OF EXPOSURE MEASUREMENT: Area air sampling/Biomonitoring (urine) / Biomonitoring blood:
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of
10, 40, or 80 ug/m3 (65, 260, 520 nmole/m3, respectively) for 8 hr.
Results and discussion
- Results:
- The correlations (r>0.90) between the air concentrations of HHPA and levels of HHP acid in plasma and urine were close. They were even closer (r>0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or sodium hydrogen carbonate did not significantly alter the excretion of HHP acid.
Any other information on results incl. tables
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 ug/m3 (65, 260, 520 nmole/m3, respectively) for 8 hr. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hydrophthalic acid (HHP acid) were seen. During the first 4 hr after the end of exposure, the half-time of HHP acid in plasma was about 2 hr. A corresponding decay was seen in urine. The correlations (r>0.90) between the air concentrations of HHPA and levels of HHP acid in plasma and urine were close. They were even closer (r>0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or sodium hydrogen carbonate did not significantly alter the excretion of HHP acid. The results show that the analysis of HHP acid in plasma or urine is useful as a biological monitor for exposure to HHPA.
Applicant's summary and conclusion
- Conclusions:
- The results show that the analysis of HHP acid in plasma or urine is useful as a biological monitor for exposure to HHPA.
- Executive summary:
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 ug/m3 (65, 260, 520 nmole/m3, respectively) for 8 hr. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hydrophthalic acid (HHP acid) were seen. During the first 4 hr after the end of exposure, the half-time of HHP acid in plasma was about 2 hr. A corresponding decay was seen in urine. The correlations (r>0.90) between the air concentrations of HHPA and levels of HHP acid in plasma and urine were close. They were even closer (r>0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or sodium hydrogen carbonate did not significantly alter the excretion of HHP acid. The results show that the analysis of HHP acid in plasma or urine is useful as a biological monitor for exposure to HHPA.
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