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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No information on guideline available. For details on materials and methods see IUCLID5 dossier.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrahydromethylphthalic anhydride
EC Number:
234-290-7
EC Name:
Tetrahydromethylphthalic anhydride
Cas Number:
11070-44-3
Molecular formula:
C9H10O3
IUPAC Name:
3a-methyl-3a,4,5,6-tetrahydro-2-benzofuran-1,3-dione
Details on test material:
- Name of test material (as cited in study report): HN-2200
- Lot/batch No.: 103

Test animals

Species:
rat
Strain:
other: Donryu
Sex:
male
Details on test animals or test system and environmental conditions:
no details given
TEST ANIMALS
- Weight at study initiation: 200g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: undiluted
Details on exposure:
no details given
Doses:
0.0336, 0.0403, 0.0483, 0.0579, 0.0834 and 0.100 ml
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: per day
- Necropsy of survivors performed: no
Statistics:
no details given

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
255 mg/kg bw
95% CL:
> 175 - < 332
Mortality:
0.100 ml/200g: 6/6 (2 days)
0.0834 ml/200g: 4/6 (2days)
0.0695 ml/200g: 3/6 (2 days)
0.0579 ml/200g: 2/6 (2 days)
0.0483 ml/200g: 2/6 (2 days)
0.0403 ml/200g: 2/6
0.0336 ml/200g: 0/6

Clinical signs:
under high concentration dose
after 4-5min: calming effects of mobility
after 30 min: respiratory paralysis and death in an abdominal position
Body weight:
no details given
Gross pathology:
no details given
Other findings:
no details given

Applicant's summary and conclusion

Conclusions:
LD50(Male, mouse, intraperitoneal) = 255 mg/kg