Registration Dossier
Registration Dossier
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EC number: 211-162-9 | CAS number: 631-61-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No specific test guideline was reported; however, a scientifically defensible approach was used to conduct the study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
- Principles of method if other than guideline:
- Chickens (Leghorn cockerels) received the intraperitonealy administration of Ammonium acetate (dissolved in 5 mL). The dose was 1375 mg/kg bw.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium acetate
- EC Number:
- 211-162-9
- EC Name:
- Ammonium acetate
- Cas Number:
- 631-61-8
- Molecular formula:
- C2H4O2.H3N
- IUPAC Name:
- ammonium acetate
- Details on test material:
- - Name of test material (as cited in study report): Ammonium acetate
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: Leghorn cockerel
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Stillwater hatchery, Stillwater, Okla., USA.
- Weight at study initiation: 190-250 g
- Diet (e.g. ad libitum): 24 hours without food before the experiments initiation.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Peritoneal administration of ammonium acetate dissolved in 5 mL of water, (or an equal volume of water-control).
- Doses:
- The dose was 1375 mg/kg bw.
- No. of animals per sex per dose:
- No data.
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 1 735 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- Dyspnea, extreme prostreation, and in some cases coma in 15-30 min.
Any other information on results incl. tables
Ammonium acetate LDLo in chicken was 1735 mg/kg bw. Caused dyspnea, extreme prostreation, and in some cases coma in 15-30 min.
Applicant's summary and conclusion
- Conclusions:
- Ammonium acetate LDLo in chicken was 1735 mg/kg bw. Caused dyspnea, extreme prostreation, and in some cases coma in 15-30 min.
- Executive summary:
Ammonium acetate LDLo in chicken 1735 mg/kg bw (peritoneal administration). Caused dyspnea, extreme prostreation, and in some cases coma in 15-30 min.
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