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EC number: 203-766-6 | CAS number: 110-42-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21 d) = 0.0814 mg/L (measured concentration) for Daphnia magna (RA CAS No. 111-82-0)
Key value for chemical safety assessment
Additional information
No data evaluating the chronic toxicity of methyl decanoate (CAS No. 110-42-9) to aquatic invertebrates are available. Therefore, data from a structurally related category member, methyl laurate (CAS No. 111-82-0) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are fatty esters esterified with methanol, differing only in the C-chain length of the fatty acid component: C10 (CAS No. 110-42-9) and C12 (CAS No. 111-82-0) respectively. The water solubility (10.6 and 7.7 mg/L for methyl decanoate and methyl laurate respectively) and log Kow values (> 4) of both substances are comparable. Therefore, a similar behavior in the water phase can be expected. Methyl laurate (CAS No. 111-82-0) exhibits the highest toxicity to aquatic organisms (Daphnia and algae) throughout the whole SCAE Me category, with EC50 and NOEC values < 1 mg/L. On the other hand, the results from the acute tests conducted on methyl decanoate (CAS No. 110-42-9) showed a lower toxicity to aquatic invertebrates and algae (EC50 > 1 mg/L). Therefore, methyl laurate is used as worst-case read across substance in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5.
One study investigating the chronic toxicity of methyl laurate (CAS No. 111-82-0) to aquatic invertebrates is available (Ministry of Environment, Government of Japan, 2006). The test was conducted according to OECD 211, under GLP conditions. Daphnia magna was exposed to the test substance for 21 d within a flow-through water regime. After the exposure period, significant effects on mortality and reproduction were observed at the highest concentrations tested (0.213 and 0.409 mg/L, measured mean), leading to a NOEC (21 d) of 0.0814 mg/L (measured mean concentration).
Based on the above information, higher toxicity than that reported in the test conducted on the structurally related category member (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), is not expected for methyl decanoate (CAS No. 110-42-9).
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