Registration Dossier
Registration Dossier
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EC number: 210-459-0 | CAS number: 616-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- The place of the range-finding test in the industrial toxicology laboratory.
- Author:
- Smyth, H.F. Jr., Carpenter, C.P.
- Year:
- 1 944
- Bibliographic source:
- J IND HYG 26:269-273, 1944.
Materials and methods
- Principles of method if other than guideline:
- no information
Test material
- Reference substance name:
- Citraconic anhydride
- EC Number:
- 210-459-0
- EC Name:
- Citraconic anhydride
- Cas Number:
- 616-02-4
- Molecular formula:
- C5H4O3
- IUPAC Name:
- 3-methyl-2,5-dihydrofuran-2,5-dione
- Details on test material:
- citraconic anhydride
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- LD50 2600 mg/kg bw. Outcome comparable to that of glycolic acid.
- Executive summary:
LD50 2600 mg/kg bw. Outcome comparable to that of glycolic acid.
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