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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study with basic documentation which meets basic scientific principles and contains sufficient detail to be able to judge the results reliable as a contribution to the understanding of the toxicity of this substance.

Data source

Reference
Reference Type:
publication
Title:
Comparative toxicological study of ethyl glycol acetate and butyl glycol acetate
Author:
Truhaut R, Dutertre-Catella H, Phu-Lich N, Ngoc Huyen V
Year:
1979
Bibliographic source:
Toxicol Appl Pharmac 51, 117-27

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: see method description below
Deviations:
not specified
Principles of method if other than guideline:
Method according to (unspecified) French regulations of 1971 which are in turn derived from the method of Draize (1959). The Draize method is the origin of the OECD test method.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butoxyethyl acetate
EC Number:
203-933-3
EC Name:
2-butoxyethyl acetate
Cas Number:
112-07-2
Molecular formula:
C8H16O3
IUPAC Name:
2-butoxyethyl acetate
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand (unspecified)
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
not specified
Controls:
no
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
6
Details on study design:
no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24 h
Score:
0.67
Max. score:
3
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
Only two of the 6 rabbits showed any response which was slight conjunctival redness and discharge in the first 24 hours. From 48hrs onwards there was no adverse effects observable.
Other effects:
none reported.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Substance has very low eye irritation potential.
Executive summary:

In an in vivo eye irritation study in which basic details are available, 2 -butoxyethyl acetate produced only very slight irritation in a few of the exposed rabbits, manifest as mild conjunctival redness, which was fully reversed within 48 hours. The response did not meet the threshold for classification as a eye irritant.

Synopsis

Not irritating.