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EC number: 231-634-8 | CAS number: 7664-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Remarks:
- Published bioaccumulation data
- Type of information:
- other: review
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Various studies summarised in EU RAR and Dutch ICD
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR summarises the results of a number of studies
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Although sodium fluoride has been identified as the test material for the current study summary, it should be noted that the publication (EU RAR for hydrogen fluoride (2001)) reports bioaccumulation data for various fluoride species, not just sodium fluoride.
- Radiolabelling:
- no
- Test organisms (species):
- not specified
- Route of exposure:
- aqueous
- Type:
- BCF
- Value:
- 53 - 58 L/kg
- Basis:
- whole body d.w.
- Remarks on result:
- other: Freshwater Fish
- Remarks:
- (Sloof et al., 1988)
- Type:
- BCF
- Value:
- < 2 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater Fish
- Remarks:
- (Sloof et al., 1988)
- Type:
- BCF
- Value:
- 3.2 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater mollusca- Chaisemartin
- Type:
- BCF
- Value:
- 7.5 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater Aquatic macrophyta - Chaisemartin
- Type:
- BCF
- Value:
- 149 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater fish
- Remarks:
- (Hemens and Warwick, 1972)
- Type:
- BCF
- Value:
- 27 - 62 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater Crustacea
- Remarks:
- (Hemens and Warwick, 1972)
- Type:
- BCF
- Value:
- 30 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater Fish
- Remarks:
- (Sloof et al., 1988)
- Conclusions:
- In freshwater aquatic organisms it was found that the fluoride accumulates primarily in the exoskeleton of crustacea and in the bones of fish. In an experimental marine ecosystem with fish, crustaceans and plants, F was found to accumulate in all species.
- Executive summary:
In freshwater aquatic organisms it was found that the fluoride accumulates primarily in the exoskeleton of crustacea and in the bones of fish. In fish, the BCF value was between 53 -58 (d.w.) and <2 (w.w.). In crustacea, BCF value was <1 (d.w.). The highest reported BCF value for mollusca and aquatic macrophyta were 3.2 and 7.5 (w.w) respectively.
In an experimental marine ecosystem with fish, crustaceans and plants, F was found to accumulate in all species. The highest value, 149, was found in marine fish. BCF values for crustacea range from 27 to 62 (Hemens and Warwick, 1972). Fluoride concentrations up to 30 mg F/kg were found in consumption fish (Slooff et al, 1988). The limited data indicate that fluoride biomagnification in the aquatic environment is of little significance. Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissue
- Endpoint:
- bioaccumulation in aquatic species, other
- Remarks:
- Published bioaccumulation data
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Hydrogen fluoride is known to rapidly react upon contact with water to form fluoride, therefore available data from studies with fluoride are given as indication of bioaccumulation properties of hydrogen fluoride.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- BCF
- Value:
- 53 - 58 L/kg
- Basis:
- whole body d.w.
- Remarks on result:
- other: Freshwater Fish
- Remarks:
- (Sloof et al., 1988)
- Type:
- BCF
- Value:
- < 2 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater Fish
- Remarks:
- (Sloof et al., 1988)
- Type:
- BCF
- Value:
- 3.2 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater mollusca- Chaisemartin
- Type:
- BCF
- Value:
- 7.5 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Freshwater Aquatic macrophyta - Chaisemartin
- Type:
- BCF
- Value:
- 149 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater fish
- Remarks:
- (Hemens and Warwick, 1972)
- Type:
- BCF
- Value:
- 27 - 62 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater Crustacea
- Remarks:
- (Hemens and Warwick, 1972)
- Type:
- BCF
- Value:
- 30 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Seawater Fish
- Remarks:
- (Sloof et al., 1988)
- Conclusions:
- In freshwater aquatic organisms it was found that the fluoride accumulates primarily in the exoskeleton of crustacea and in the bones of fish. In an experimental marine ecosystem with fish, crustaceans and plants, F was found to accumulate in all species.
- Executive summary:
Hydrogen fluoride is known to rapidly react upon contact with water to form fluoride, therefore available data from studies with fluoride are given as indication of bioaccumulation properties of hydrogen fluoride.
In freshwater aquatic organisms it was found that the fluoride accumulates primarily in the exoskeleton of crustacea and in the bones of fish. In fish, the BCF value was between 53 -58 (d.w.) and <2 (w.w.). In crustacea, BCF value was <1 (d.w.). The highest reported BCF value for mollusca and aquatic macrophyta were 3.2 and 7.5 (w.w) respectively.
In an experimental marine ecosystem with fish, crustaceans and plants, F was found to accumulate in all species. The highest value, 149, was found in marine fish. BCF values for crustacea range from 27 to 62 (Hemens and Warwick, 1972). Fluoride concentrations up to 30 mg F/kg were found in consumption fish (Slooff et al, 1988). The limited data indicate that fluoride biomagnification in the aquatic environment is of little significance. Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissue
Referenceopen allclose all
The limited data indicate that fluoride biomagnification in the aquatic environment is of little significance. Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissues.
The limited data indicate that fluoride biomagnification in the aquatic environment is of little significance. Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissues.
Description of key information
Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissue
Key value for chemical safety assessment
- BCF (aquatic species):
- 149 L/kg ww
Additional information
In freshwater aquatic organisms it was found that the fluoride accumulates primarily in the exoskeleton of crustacea and in the bones of fish. In fish, the BCF value was between 53 -58 (d.w.) and <2 (w.w.). In crustacea, BCF value was <1 (d.w.). The highest reported BCF value for mollusca and aquatic macrophyta were 3.2 and 7.5 (w.w) respectively.
In an experimental marine ecosystem with fish, crustaceans and plants, F was found to accumulate in all species. The highest value, 149, was found in marine fish. BCF values for crustacea range from 27 to 62. Fluoride concentrations up to 30 mg F/kg were found in consumption fish. The limited data indicate that fluoride biomagnification in the aquatic environment is of little significance. Fluoride accumulates in aquatic organisms predominantly in the exoskeleton of crustacea and in the skeleton of fish; no accumulation was reported for edible tissue
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