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Neurotoxicity

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One published study is available

Key value for chemical safety assessment

Additional information

Fluoride exposure caused sex and dose specific behavioural disruption (as measured by computer pattern recognition in a novel environment), with a common pattern. Males were most sensitive to prenatal day 17 -19 exposure, whereas females were more sensitive to weanling and adult exposures. After fluoride ingestion, the severity of the effect on behaviour increased directly with plasma F levels and F concentrations in specific brain regions (Mullenix et al, 1995).

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