Registration Dossier
Registration Dossier
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EC number: 231-634-8 | CAS number: 7664-39-3
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The metabolism of fluorides in man
- Author:
- Largent EJ
- Year:
- 1 960
- Bibliographic source:
- Archives of Industrial Health 21; 318-323
- Reference Type:
- publication
- Title:
- Fluorosis: The Health Aspects of Fluorine Compounds
- Author:
- Largent EJ
- Year:
- 1 961
- Bibliographic source:
- Ohio State University Press
Materials and methods
- Type of study / information:
- Human volunteer studies
- Endpoint addressed:
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Assessment of irritant effects in exposed volunteers
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- Molecular formula:
- FH
- IUPAC Name:
- hydrogen fluoride
- Details on test material:
- Gaseous HF
Constituent 1
Method
- Details on study design:
- Volunteers were exposed for 6 hours/day; 15-50 days to low concentrations of HF and irritant effects were assessed.
- Exposure assessment:
- measured
Results and discussion
Any other information on results incl. tables
No systemic effects were observed. Mild discomfort (slight eye stinging, slight stinging of the facial skin, slight irritation of the nasal mucosa) was reported at concentrations of up to 2 ppn (1.64 mg/m3). At higher concentrations, erythema and desquamation of the superficial epithelium of the facial skin was observed. Symptoms of mild irritation resolved with cessation of exposure, erythema persisted for a short period of time.
Applicant's summary and conclusion
- Conclusions:
- Exposure of human volunteers to low concentrations of HF resulted in mild and reversible irritant effects.
- Executive summary:
Volunteers were exposed for 6 hours/day; 15-50 days to low concentrations of HF and irritant effects were assessed. No systemic effects were observed. Mild discomfort (slight eye stinging, slight stinging of the facial skin, slight irritation of the nasal mucosa) was reported at concentrations of up to 2 ppm (1.64 mg/m3). At higher concentrations, erythema and desquamation of the superficial epithelium of the facial skin was observed. Symptoms of mild irritation resolved with cessation of exposure, erythema persisted for a short period of time. No effects were reported at the lowest concentration of 1.42 ppm (1.16 mg/m3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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