Registration Dossier
Registration Dossier
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EC number: 203-751-4 | CAS number: 110-27-0
Endpoint summary
Administrative data
Description of key information
Additional information
No studies on long-term terrestrial toxicity are available for this substance. Due to the high Koc a considerable adsorption to sediment and soil is indicated. However, all members of the category have been shown to be readily biodegradable. Therefore, no chronic exposure of terrestrial organisms is expected. Furthermore, a valid short term toxicity test on Eisenia fetida is available within this category, indicating no toxicity. In addition, Fatty acid esters are readily metabolised in Fatty acids and alcohols. These components occur in sediment and soils naturally, are part of physiological pathways and can be used as energy source. The enzyme carboxylesterase is omnipresent in the environment, readily degrading the test substances of this category. Thus, toxic effects caused by the metabolites of fatty acid esters are implausible.
In conclusion, due to a) the observed absence of toxicological effects on aquatic and sediment organisms, b) the lack of chronic exposure and c) the, acknowledged metabolisation of fatty acid esters, toxic effects to terrestrial organisms can be excluded.
A study on Eisenia fetida served as indicator for the low toxicity of the category members on terrestrial organisms. In this short-term study according to OECD guideline 207, Isopropyl myristate (CAS: 110-27-0) was tested, using artificial soil, resulting in a LC50(14d) > 20000 mg/kg dw (Steber 1999).
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