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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only summary data provided with limited information on methods and results.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Final report on the safety assessment of propylene carbonate
Author:
Beyer KH Jr., Bergfeld WF, Berndt, WO, et al.
Year:
1987
Bibliographic source:
Journal of the American College of Toxicology Vol 6, (1)

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
2 weeks
Frequency of treatment:
Daily
Doses / concentrations
Dose / conc.:
1 000 other: mg/kg
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The test substance failed to produce pharmacotoxic effects or pathological changes.

Applicant's summary and conclusion